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. 2013 Apr 1;8(4):e60266. doi: 10.1371/journal.pone.0060266

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© 2013 Yuan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The concentration - time curve of SANT75 in plasma after intravenous administration of liposomal SANT75 or free SANT75 to rats. (B) Pharmacokinetic parameters after intravenous administration of liposomal SANT75 or free SANT75 to rats. The results are expressed as the mean ± SD. (C) The tissue distribution of free SANT75 in tumor-bearing mice at different time point. Columns, mean; bars, SD. (D) The tissue distribution of liposomal SANT75 in tumor-bearing mice at different time point. Columns, mean; bars, SD. (E) The drug distribution of free SANT75 or liposomal SANT75 in tumor tissues at different time point.