Figure 2. N-glycan precursor biosynthesis pathway under glucose deprivation in T24 cells.

The solid and dotted arrows indicate activated and repressed metabolite flows, respectively. Note that the production of N-GlcNAc₂-modified proteins under conditions of glucose deprivation is promoted by (i) up-regulation of the UDP-GlcNAc biosynthesis pathway and (ii) suppression in the addition of a mannose residue to dolichol-PP-GlcNAc₂.