Figure 8. A schematic summary of all the experimental results.

The dotted arrows show the transfer of molecules. The thick crosses signify an inhibition in the transfer of molecules. The solid thin arrows indicate activation or repression of targets. The solid thick arrows signify either an increase (up arrow) or decrease (down arrow) in the level of the corresponding molecules. The solid and dotted squares surrounding the gene names indicate up- and down-regulated gene expression, respectively. Note that N-GlcNAc₂-modified proteins accumulated in the ER induce G2/M transition arrest via the unfolded protein response (UPR) under conditions of glucose-deprivation.