Table 5. Standardized incidence ratios (SIRs) for malignancies in Japan-resident Werner syndrome patients.^*** .

tumor	observed****	expected****	SIR	95% CI
melanoma of skin	9	0.17	53.5*	(24.5, 101.6)
meningioma	10	0.28	36.2*	(17.3, 66.5)
soft tissue	11	0.35	31.1*	(15.5, 55.7)
bone	9	0.33	27.1*	(12.4, 51.4)
thyroid	14	1.57	8.9*	(4.9, 15.0)
leukemia	5	2.47	2.0	(0.66, 4.7)
all sites**	90	103.81	0.87	(0.70, 1.07)

^*statistically significant result (p<0.05).

^**includes benign meningiomas diagnosed prior to 1988, but excludes non-melanoma skin neoplasms.

^***for patients with high WS diagnostic confidence (1965–2009).

^****relative to Osaka, Japan population, 1965–2009.

note: analysis conditioned on a WRN pathogenic allele frequency of q = 0.0037.