Table 6. Median ages and age ranges for cancer in Werner syndrome versus other cancer predisposition syndromes.
| neoplasm* | Werner syndrome**(n = 146) | Bloom syndrome*** (n = 104) | Rothmund-Thomson syndrome**** (n = 19) | Osaka Cancer Registry (n = 2,828) | Osaka population***** (n = 785,798) | US SEER data | |
| melanoma of skin | 44 (34, 59) | 0 | – | 60 (2, 96) | 62 (2, 85+) | 61.0 | |
| meningioma | 39 (22, 67) | 9 | – | 61 (0, 99) | – | – | |
| soft tissue | 43 (26, 58) | 0 | – | na | 52 (2, 85+) | 58.0 | |
| bone | 49 (20, 57) | (4, 15) | 12 (3, 31) | na | 47 (2, 85+) | 41.0 | |
| thyroid | 40 (25, 46) | 0 | – | na | 57 (2, 85+) | 50.0 | |
| leukemia | 45 (28, 62) | 15 (2, 39) | – | na | 52 (2, 85+) | 66.0 | |
| all sites excluding skin | 44 (20, 82) | 24 (0, 48) | 12 (2, 31) | na | 67 (2, 85+) | – | |
| all sites | 44.5 (20, 82) | 25 (0, 48) | 12 (2, 31) | na | 67 (2, 85+) | 66.0 | |
malignant cases only, except for meningiomas where benign cases were also included.
Japan-residents cases only, excluding tumor cases with ambiguous age at diagnosis.
BS = Bloom syndrome. Some discrepancies between data given in Figure 2 and Table 4 of reference [23].
RTS = Rothmund-Thomson syndrome [25]. Note that adding 6 additional tumor cases reported in patients with RAPADILINO syndrome, which is also caused by mutations in RecQL4, has minimal effect (all sites estimate becomes 13 (2, 33)).
Osaka population ages given by 5-year age groups, so medians are approximate. Data obtained from CI5plus online application (years 1963–2002); soft tissue and all sites data from CI5 volumes 3–9 (years 1970–2002) [7]. SEER data from [35].
na = not accessed.