H3K9 acetylation (H3K9ac) is overrepresented and H3K27 trimethylation (H3K27me3) is underrepresented in PC
cis-NAT-encoding genes relative to PC non-cis-NAT-encoding genes with similar expression levels. PC
cis-NAT genes and PC non-cis-NAT genes are partitioned to three bins based on expression levels. Genes were binned into low, medium, and high groups based on their transcript abundances (2–16 RPKM, 16–128 RPKM, and more than 128 RPKM, respectively). Asterisks indicate that the proportion of PC
cis-NAT (PC non-cis-NAT) genes with a given chromatin modification is significantly greater than the proportion of PC non-cis-NAT (PC
cis-NAT) genes as follows: ***P < 1e-03, **P < 1e-02, *P < 5e-02. A, The proportions of PC
cis-NAT-encoding genes and PC non-cis-NAT-encoding genes with H3K27me3 are noted on the y axis. A significantly lower proportion of PC
cis-NAT genes are marked with H3K27me3 than are PC non-cis-NAT genes across all expression levels. B, The proportions of PC
cis-NAT-encoding genes and PC non-cis-NAT-encoding genes marked with H3K9ac are noted on the y axis. The frequency of H3K9ac among PC
cis-NAT genes is significantly higher than the frequency among PC non-cis-NAT genes. [See online article for color version of this figure.]