Table 5.
Effect of I405V CETP Genotypes on biochemical analytes among controls and patients and according to gender
| Controls (n = 117) | ||||
|---|---|---|---|---|
| Parameters | II (n = 32) | IV (n = 66) | VV (n = 19) | P value |
| TC (mg/dl) | 198.59 ± 25.11 | 193.27 ± 30.80 | 185.16 ± 20.62 | 0.255 |
| HDL-C (mg/dl) | 48.28 ± 11.59 | 50.29 ± 8.94 | 52.26 ± 9.84 | 0.367 |
| HDL2-C (mg/dl) | 10.94 ± 7.32 | 13.14 ± 6.04 | 13.42 ± 4.68 | 0.217 |
| HDL3-C (mg/dl) | 37.34 ± 7.95 | 37.15 ± 7.07 | 38.84 ± 6.91 | 0.669 |
| TC/HDL-C | 4.41 ± 1.38 | 3.97 ± 0.94 | 3.65 ± 0.70 | 0.033 |
| Apo A1 (g/l) | 1.27 ± 0.2 | 1.25 ± 0.18 | 1.25 ± 0.15 | 0.919 |
| Apo B (g/l) | 1.05 ± 0.18 | 1.02 ± 0.22 | 0.92 ± 0.14 | 0.097 |
| LDL-C (mg/dl) | 124.69 ± 22.87 | 121.05 ± 25.95 | 111.37 ± 19.42 | 0.162 |
| sdLDL (mg/dl) | 22.63 ± 10.44 | 20.48 ± 9.78 | 15.47 ± 7.04 | 0.038 |
| Males (n = 81) | ||||
| II (n = 20) | IV (n = 47) | VV (n = 14) | ||
| HDL-C (mg/dl) | 42.70 ± 7.42 | 48.0 ± 8.05 | 51.36 ± 10.27 | 0.01 |
| HDL2-C (mg/dl) | 8.75 ± 4.31 | 12.06 ± 5.44 | 13.50 ± 4.96 | 0.018 |
| sdLDL (mg/dl) | 27.0 ± 10.64 | 21.89 ± 9.05 | 17.14 ± 7.43 | 0.011 |
| Patients (n = 119) | ||||
| II (n = 39) | IV (n = 60) | VV (n = 20) | ||
| TC (mg/dl) | 169.00 ± 44.23 | 156.2 ± 35.93 | 139.15 ± 30.11 | 0.018 |
| HDL-C (mg/dl) | 32.21 ± 8.00 | 36.82 ± 8.33 | 34.55 ± 7.78 | 0.025 |
| HDL2-C (mg/dl) | 10.00 ± 4.32 | 10.85 ± 4.70 | 11.4 ± 4.44 | 0.484 |
| HDL3-C (mg/dl) | 22.21 ± 5.16 | 25.97 ± 6.37 | 23.15 ± 5.17 | 0.006 |
| TC/HDL-C | 5.36 ± 1.16 | 4.37 ± 1.08 | 4.27 ± 1.11 | <0.0001 |
| Apo A1 (g/) | 0.95 ± 0.14 | 1.03 ± 0.17 | 0.95 ± 0.14 | 0.022 |
| Apo B (g/l) | 1.07 ± 0.23 | 0.96 ± 0.24 | 0.86 ± 0.19 | 0.005 |
| LDL-C (mg/dl) | 112.72 ± 35.24 | 99.13 ± 28.58 | 87.30 ± 26.37 | 0.009 |
| sdLDL (mg/dl) | 16.90 ± 8.17 | 12.87 ± 7.34 | 12.00 ± 6.51 | 0.016 |
P values calculated using one way analysis of variance (ANOVA)