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mRNA destabilization occurs mainly through sites located in the 3′ UTR. Shown are log2 fold changes in mRNA levels upon miRNA transfection in the experiments of (A) Linsley et al. (2007) and (B) Grimson et al. (2007). mRNAs with binding sites located in the CDS only, in the 3′ UTR only, and in both CDS and in 3′ UTR were analyzed separately. Fold changes were normalized to the average fold change of mRNAs that did not contain canonical binding sites to the transfected miRNA.
