Table 3.
Regions of significantly reduced gray matter density in bvFTD patients relative to demographically matched healthy seniors (p < 0.05 FDR-corrected; 100 voxel extent).
| Neuroanatomic Region (BA) | L/R | Peak MNI coordinate |
Z-score | Voxels | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Rostromedial prefrontal (10) | M | −6 | 50 | 16 | 4.63 | 4163 |
| Rostral prefrontal (10) | L | −26 | 52 | 4 | 4.31 | 297 |
| Rostral prefrontal (10) | L | −26 | 44 | 30 | 3.96 | 254 |
| Inferior frontal (44/45) | R | 50 | 4 | 22 | 3.81 | 385 |
| Dorsolateral prefrontal (9) | L | −40 | 2 | 38 | 4.11 | 154 |
| Anterior cingulate (24) | L | −18 | −10 | 24 | 3.77 | 111 |
| Insula (12) | L | −38 | 12 | 4 | 3.29 | 135 |
| Medial temporal (21) | L | −38 | −24 | −16 | 4.17 | 578 |
| Anterior temporal (38) | L | −36 | 8 | −26 | 3.86 | 176 |
| Anterior temporal (38) | R | 42 | 10 | −30 | 3.76 | 347 |
| Posterior-lateral temporal (22) | R | 52 | −26 | 0 | 3.54 | 110 |