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Crystal structure shows that CIC21 binds to a highly hydrophobic pocket of the AXH domain. (A) Ribbon representation of the AXH domain (blue) and the bound CIC21 peptide shown in ball-and-stick (yellow). (B) Detailed interaction between the AXH domain and CIC21 peptide showing that CIC21 binds to the hydrophobic pocket in the AXH domain. (C) Electrostatic surface representation of the AXH domain bound with CIC21 (yellow) showing hydrophobic character of the pocket.
