Figure 3.
Crystal structure showing CIC28-mediated heterotetramer formation with the AXH domain. (A) Ribbon representation of the AXH–CIC28 structure showing that CIC28 reconfigures the complex formation of the AXH domain (the AXH domain is shown in blue and light blue, and the CIC28 peptide is shown in yellow and purple). (B) Detailed structure between AXH–CIC28 and the other CIC28 peptide (shown in the dashed box in the top panel of A). (C) Detailed structure of the hydrophobic core where two AXH domains and two CIC28 peptides interact (shown in the dashed box in the bottom panel of A).