Table 4.

Group comparisons between clusters.

Variables	Control (n = 194)	Cluster 1 (n = 21)	Cluster 2 (n = 32)	Cluster 3 (n = 15)	ANOVA p-value	Pair-wise comparisons (alpha 0.01)
Age (mean ± SD)	46.75 ± 11.13	45.70 ± 9.32	47.26 ± 9.97	44.70 ± 7.70	0.85	–
CAG (mean ± SD)	20.12 ± 3.45	43.58 ± 2.59	43.22 ± 3.66	42.73 ± 2.09	<0.001	Control < C1, C2, C3
UHDRS
Total motor
(mean ± SD)	2.75 ± 3.08	16.52 ± 5.60	9.56 ± 6.03	11.86 ± 6.78	<0.001	Control < C2, C3 < C1
Motor domains
Oculo (mean ± SD)	0.65 ± 1.23	4.52 ± 2.36	2.34 ± 2.89	3.57 ± 3.06	<0.001	Control < C2 < C1; Control < C3
Brady (mean ± SD)	1.44 ± 1.91	6.67 ± 3.12	4.03 ± 3.10	3.79 ± 2.81	<0.001	Control < C2, C3 < C1
Rigidity (mean ± SD)	0.31 ± 0.68	0.67 ± 1.15	0.53 ± 0.72	0.92 ± 1.07	0.004	Control < C3
Dystonia (mean ± SD)	0.06 ± 0.34	1.05 ± 1.56	0.38 ± 0.87	0.43 ± 0.76	<0.001	Control < C2 < C1; C3 < C1
Chorea (mean ± SD)	0.29 ± 0.69	3.62 ± 2.52	2.28 ± 2.05	3.14 ± 2.28	<0.001	Control < C1, C3; C2 < C1
Cognition (mean ± SD)	341.4 ± 47.4	224.0 ± 25.7	303.8 ± 19.4	361.8 ± 22.6	<0.001	C1 < C2 < Control, C3
Behavior (mean ± SD)	5.69 ± 9.29	12.65 ± 18.63	20.25 ± 21.28	7.47 ± 10.05	<0.001	Control, C3 < C2

Cluster 1, predominantly cognitive; Cluster 2, predominantly behavioral; Cluster 3, cognitively preserved.