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. 2012 Aug 24;27(2):336–343. doi: 10.1038/leu.2012.221

Figure 5.

Figure 5

γ-Catenin overexpression promotes TCF/LEF-mediated transcription in leukemic cells. (a, b, c) Representative flow cytometric histograms showing TCF reporter activity (Venus EYFP) in control (Cont TCF) or γ-catenin-transduced (γ-Cat TCF) K562, THP-1 and U937 cells. Autofluorescence levels (Autofluor.) were established using parental cells. Background fluorescence arising from construct integration is indicated by control cells transduced with an identical construct bearing mutated TCF-binding sites (Mutant TCF). (d) Summary data showing the relative Venus EYFP intensity obtained from control or γ-catenin-transduced K562, THP-1 and U937 cell lines. Data represents mean±1 s.d., n=3. Statistical significance is denoted by †P<0.01 and ‡P<0.05, as analyzed by Student's t-test.