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. 2013 Mar 6;136(4):1128–1138. doi: 10.1093/brain/awt037

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© The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Endogenous mouse α-synuclein was aggregated in wild-type mouse brain injected with human α-synuclein (hsyn) fibrils. The brain was divided into two parts at the longitudinal fissure of the cerebrum. Sarkosyl-insoluble fractions were obtained from the right and left hemispheres, and analysed by immunoblotting with #64, LB509 or anti-mouse α-synuclein (msyn) antibodies. Representative images are shown (n = 14). Sarkosyl-insoluble phosphorylated α-synuclein (psyn) started to accumulate, predominantly in the right hemisphere, at 90 days after injection. It was composed of endogenous mouse α-synuclein, not exogenous human α-synuclein.