Table 3.
Hyperemesis gravidarum and risk of placental abruption, stillbirth and giving birth to a small for gestational age (SGA) infant
| Hyperemesis gravidarum | Placental abruption | Stillbirth* | Small for gestational age** | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. | Rate (%) | AOR*** (95% CI) | No. | Rate (%) | AOR*** (95% CI) | No. | Rate (%) | AOR*** (95% CI) | |
| No | 4652 | 0.4 | Reference | 3628 | 0.3 | Reference | 26 683 | 2.4 | Reference |
| Yes | 64 | 0.5 | 1.47 (1.10–1.95) | 41 | 0.3 | 0.99 (0.68–1.44) | 381 | 3.1 | 1.18 (1.04–1.33) |
| First trimester (<12 weeks) | 42 | 0.4 | 1.13 (0.80–1.61) | 35 | 0.3 | 0.95 (0.62–1.44) | 298 | 2.9 | 1.13 (0.99–1.30) |
| Second trimester (12–21 weeks) | 22 | 1.1 | 3.07 (1.88–5.00) | 6 | 0.3 | 1.18 (0.53–2.64) | 83 | 4.0 | 1.39 (1.06–1.83) |
AOR, adjusted odds ratio; CI, confidence interval.
*
Only births ≥28 gestational weeks were included.
**
Defined as a live-born infant with a birthweight for gestational age of less than two standard deviations below the sex-specific Swedish fetal growth curve.18
***
Adjustments were made for maternal age, parity, body mass index, height, smoking, cohabitation with infant's father, infant's sex, mother's country of birth and years of formal education, presence of hyperthyreosis, pregestational diabetes or chronic hypertension, and year of birth of infant.