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. 2013 Apr 2;3:72. doi: 10.3389/fonc.2013.00072

Figure 3.

Figure 3

Quantification of relative tumor volume 14 days after a single 11.6 Gy fraction or two 7.3 Gy fraction radiation treatments. Lung cancers in (A) LSL-Kras; Ink4a/ARFFL/FL and (B) LSL-Kras; p53FL/FL mice were imaged prior to radiation therapy (Day 0) and 2 weeks after radiation therapy (Day 14). Graphs show the average fold change for the lung tumors at 14 days.(A) Lung cancers in LSL-Kras; Ink4a/ARFFL/FL mice show improved response to two 7.3 Gy fractions separated by 24 h compared to a single 11.6 Gy treatment as measured by micro-CT at 14 days after radiation treatment (P = 0.002). (B) Lung cancers in LSL-Kras; p53FL/FL mice respond to a single 11.6 Gy fraction and two 7.3 Gy fractions of radiation therapy with a small difference that is not statistically significant as measured by micro-CT at 14 days after radiation treatment (P = 0.23). Error bars – SEM.