Table 3.

Moderating effect of apolipoprotein E (apoE4) status on the relationship between top sex-specific quartile of waist-to-hip ratio (Q4) and brain volume.

	Overall (Beta ± SE)+	P-value for Interaction with ApoE4	ApoE4 Absent (2/2, 2/3, 3/3) (Beta ± SE)+	ApoE4 Present (3/4, 4/4) (Beta ± SE)+
Total Brain Volume	−0.197±0.045***	0.892	−0.203±0.050***	−0.189±0.096
White Matter Hyperintensities	0.018±0.047	0.033	−0.038±0.054	0.199±0.095*
Frontal Lobe Volume	−0.258±0.046***	0.047	−0.313±0.052***	−0.097±0.095
Temporal Lobe Volume	−0.095±0.051	0.817	−0.092±0.059	−0.120±0.101
Temporal Horn Volume	0.130±0.049**	0.612	0.142±0.056*	0.083±0.101
Lateral Ventricular Volume	0.141±0.048**	0.162	0.108±0.056	0.267±0.090**
Hippocampal Volume	−0.029±0.054	0.148	−0.075±0.062	0.109±0.108

Note.

^*p<0.05;

^**p<0.01;

^***p<0.001;

⁺adjusted difference in means comparing participants in Q4 to those in Q1–Q3