Table 5.

Moderating effect of apolipoprotein E (apoE4) status on the relationship between top sex-specific quartile of BMI (Q4) and brain volume.

	Overall (Beta ± SE)+	P-value for Interaction with ApoE4	ApoE4 Absent (2/2, 2/3, 3/3) (Beta ± SE)+	ApoE4 Present (3/4, 4/4) (Beta ± SE)+
Total Brain Volume	−0.152±0.043***	0.142	−0.119±0.048*	−0.277±0.099**
White Matter Hyperintensities	−0.115±0.046*	0.133	−0.150±0.051	0.020±0.099
Frontal Lobe Volume	−0.329±0.044***	0.704	−0.358±0.050***	−0.316±0.097**
Temporal Lobe Volume	−0.096±0.049	0.686	−0.088±0.056	−0.137±0.104
Temporal Horn Volume	0.068±0.048	0.296	0.043±0.054	0.167±0.104
Lateral Ventricular Volume	0.044±0.047	0.046	−0.001±0.053	0.229±0.093*
Hippocampal Volume	0.006±0.052	0.489	0.025±0.059	−0.064±0.111

Note.

^*p<0.05;

^**p<0.01;

^***p<0.001;

⁺adjusted difference in means comparing participants in Q4 to those in Q1–Q3