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. 2013 Mar 7;4(3):e525. doi: 10.1038/cddis.2013.54

Figure 1.

Figure 1

Minocycline treatment suppressed the disease in SOD1G93A mice. (a) The lifespan of SOD1G93A mice was 168.2±11.3 days (n=19) and that of minocycline-treated ones was 195.1±15.5 days (n=20; P<0.01). (b) The disease onset of SOD1G93A mice, as determined by a decrease in rotarod performance at 15 r.p.m., was 140.4±13.1 days. The disease onset of minocycline-treated mice was delayed to 161.0±18.4 days (P<0.01). (c) The disease duration of SOD1G93A mice, as determined by 15 r.p.m. rotarod performance, was 27.8±2.9 days. That of minocycline-treated SOD1G93A mice was 33.7±3.9 days. Black line, SOD1G93A mice; gray line, minocycline-treated SOD1G93A mice. Open column, SOD1G93A mice; closed column, minocycline-treated SOD1G93A mice. Error bars, S.E. NS, not significant