Figure 4.
Minocycline did not affect the transient enhancement of M2 markers in early phase pathogenesis. RNA was extracted from the lumbar spinal cords. The temporal mRNA expression profiles of M2 markers ((a) CD206, (b) arginase1, (c) IL-4, (d) IL-10, and (e) Ym1) were examined by quantitative RT-PCR. Open columns, SOD1G93A mice (n=4); closed columns, minocycline-treated SOD1G93A mice (n=3). Error bars, S.E. All expression profiles were not significant in two-way ANOVA. #P<0.05, ##P<0.01 compared with 9 weeks mice