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. 2013 Apr 2;3:62. doi: 10.3389/fonc.2013.00062

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Copyright © 2013 Baldock, Rockne, Boone, Neal, Hawkins-Daarud, Corwin, Bridge, Guyman, Trister, Mrugala, Rockhill and Swanson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Scatter plot of relative hypoxia (RH, the ratio of hypoxic volume to T2-weighted MRI volume) versus ρ/D for n = 11 glioblastoma patients. RH was determined over a variety of tissue to blood (T/B) tracer levels, ranging from 1.1 to 1.6 in increments of 0.1. A strong linear relationship between the variables is shown for all thresholds; correlations were statistically significant for all T/B levels considered. From Szeto et al. (2009b), with permission from Nature Publishing Group, Cancer Research.