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Simulated FMISO-PET and actual FMISO-PET. Hypoxia is predicted by the PIHNA model and an imaging reconstruction algorithm produces the simulated FMISO-PET. Pixel intensity distribution is not statistically different between the two images, providing model-based predictions of tumor hypoxia which is otherwise obscured by PET image acquisition and reconstruction. Courtesy: Gu et al. (2012), by permission of Oxford University Press.
