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. 2013 Mar 1;123(4):1580–1589. doi: 10.1172/JCI60083

Figure 4. Inhibition of STAT3 signaling ablates the suppressive activity of CD14+HLA-DR–/lo MDSC from HNSCC patients.

Figure 4

Both pSTAT3 small molecule inhibitor (Stattic at 10 μM) (A and C), and STAT3 siRNA (B and D) were able to block the functional suppressive capability of blood (A and B) and tumor-infiltrating (C and D) MDSC (**P < 0.01). x axis shows the ratio of autologous T cell/MDSC in the T cell stimulation assay.