Skip to main content
. 2013 Mar 15;123(4):1821–1832. doi: 10.1172/JCI64398

Figure 6. Increased bone mass, knee joint pathology, and inflammatory cytokines in the Gsk3a KO mice.

Figure 6

(A) Representative micro-CT scans (in blue) and histological images of the knee. BV/TV, analyzed by micro-CT, was increased strikingly in the knees of the KO mice at 12 and 24 months of age. Values indicate BV/TV for each group. Calcification in the aging knees of the KO mice is also evident by both micro-CT and histology. There is fusion of the joint space and meniscus of the knee at 24 months of age. Original magnification, ×40. (B) Representative immunohistochemistry images from the knees of WT or Gsk3a KO mice, stained for inflammatory cytokines MMP-13 and IL-1. MMP-13 staining (brown stain) is increased in the KO bone marrow at 12 months and remains elevated at 24 months. IL-1 staining (brown stain) is also increased in the osteocytes and bone marrow of the KO mice at 12 months, indicating elevated inflammatory cytokines in the KO mice. Original magnification, ×100.