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. 2013 Mar 15;123(4):1662–1676. doi: 10.1172/JCI65538

Figure 2. Absence of liver GLUT2 expression suppresses hepatic glucose uptake but does not impair endogenous glucose production.

Figure 2

(A) PET imaging of 18FDG uptake by the liver and kidneys of control and LG2KO mice during the first 15 minutes after injection (dorsal view; red, high uptake; green, low uptake). (B) Kinetics of 18FDG uptake by the liver of control (white squares, n = 6) and LG2KO (black circles, n = 8) mice. Note the suppression of 18FDG uptake between 1 minute and 9 minutes after injection in the liver of LG2KO mice. **P < 0.01 versus control mice. (C) Time-activity curve of 18FDG uptake in the blood of control (white squares, n = 6) and LG2KO (black circles, n = 8) mice acquired by imaging the inferior vena cava. Inset shows expanded view of the same graph from 0 to 3 minutes after tracer injection. (D) Endogenous glucose production by control and LG2KO mice (n = 10). (E) Evolution of blood glucose levels in fasted control and LG2KO mice (n = 9). ***P < 0.001 versus control mice. (F) Evolution of hepatic glycogen content in control and LG2KO mice in the indicated states (n = 5). **P < 0.01. Rd, rate of glucose disappearance; HGO, hepatic glucose output.