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. 2013 Mar 1;123(4):1457–1474. doi: 10.1172/JCI65579

Figure 8. Elevated levels of IgG4 antibodies in patient sera correlate with patient survival.

Figure 8

(A) IgG subclass ELISA evaluations of sera from 33 patients with stage III and IV melanoma were evaluated using Spearman correlation analyses for IgGsubclass/IgGtotal, fractions in relation to patient survival (months), showing a statistically significant negative correlation between IgG4 fraction only (r = –0.32; P = 0.00353). (B) Kaplan-Meier cumulative survival analysis of overall patient survival was compared with respect to IgG4/IgGtotal fractions (stratified according to fractions above (blue) or below (black) the 75 percentile of the IgG4/IgGtotal fractions measured from the 33 metastatic melanoma patient cohort), indicating that high IgG4/IgGtotal ratios in sera are associated with a significantly lower overall survival (P = 0.003; hazard ratio 0.19; 95% CI 0.0635–0.5685).