Figure 1.

Pathologic features of AKI associated with SPICE. (A) Injured proximal tubular epithelial cells show apical blebbing from the surface and cytoplasmic vacuolization. Rare intraluminal detached necrotic tubular epithelial cells are also present. These findings are indicative of acute tubular injury. (B) Proximal tubular dilation with epithelial cell vacuolization and apical blebbing. Areas of denuded tubular basement membranes indicating focal epithelial cell loss are also identified. There is also accompanying interstitial edema. (C) The morphologic features of acute tubular injury are similar to the first two patients. All stained with periodic acid–Schiff. Original magnification, ×400 in A and B; ×200 in C.