Table 3.

ORs and 95% CIs of elevated serum β-trace protein (≥0.81 mg/L), elevated serum β2-microglobulin (≥2.80 mg/L), and elevated serum cystatin C (≥1.03 mg/L) in persons aged ≥20 years adjusted for eGFR

	β-Trace Protein (≥0.81 mg/L)			β2-Microglobulin (≥2.80 mg/L)			Standard Cystatin C (≥1.03 mg/L)
	≥20 yr (n=6682 [1220])			≥20 yr (n=6688 [1204])			≥20 yr (n=6742 [1680])
	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
eGFR creatinine	0.92	0.90–0.93	<0.01	0.92	0.91–0.94	<0.01	0.91	0.90–0.92	<0.01
BMI (per 5 kg/m2 increase)	0.80	0.68–0.95	0.01	0.74	0.66–0.82	<0.01	1.10	0.96–1.26	0.15
Hypertension	1.99	1.37–2.90	<0.01	1.70	1.36–2.14	<0.01	1.71	1.18–2.46	0.01
Diabetes	1.03	0.67–1.59	0.88	1.51	0.92–2.47	0.10	1.48	0.96–2.28	0.08
Current smoker	0.89	0.55–1.44	0.64	0.82	0.54–1.24	0.34	1.35	0.91–2.01	0.13
CRP (mg/dl)a
0.22–1.0	1.26	0.90–1.78	0.18	1.90	1.39–2.59	<0.01	1.11	0.85–1.45	0.42
>1.0	2.00	1.24–3.25	0.01	5.70	3.52–9.24	<0.01	3.52	2.02–6.15	<0.01
Triglycerides (mg/dl)	0.56	0.36–0.88	0.01	0.75	0.55–1.03	0.07	1.22	0.82–1.80	0.32
HDL (per 10 mg/dl increase)	0.82	0.72–0.94	<0.01	0.80	0.71–0.90	<0.01	0.84	0.76–0.92	<0.01
Education ≥12 yr	0.56	0.41–0.76	<0.01	0.60	0.47–0.77	<0.01	0.59	0.46–0.76	<0.01

Numbers in brackets represent individuals with an elevated β-trace protein (≥0.81 mg/L) and elevated β2-microglobulin (≥2.80 mg/L). Triglycerides were analyzed on a logarithmic scale (ln). Triglycerides may be converted from mg/dl to mmol/L by multiplying by 0.0113. HDL may be converted from mg/dl to mmol/L by multiplying by 0.0259. OR, odds ratio; 95% CI, confidence interval; eGFR, estimated GFR; BMI, body mass index; CRP, C-reactive protein.

^aReference group is individuals with CRP <0.22 mg/dl.