FIG. 6.

Geminin overexpression decreases proliferation and increases the length of the G2/M phase. (A) Control and Geminin ESC were grown for 2 days in the absence of LIF and Dox and then plated to assay proliferation. Geminin overexpression reduced proliferation at 4 (*P≤0.005) and 6 days (**P≤0.0001) after Dox withdrawal; Student's t-test, n=3. (B) Cell cycle analysis after 6 days of Dox withdrawal. Geminin overexpression increased the length of G2/M (*P≤0.05) and decreased the length of G1 (**P≤0.03 Student's t-test, n=3). Color images available online at www.liebertpub.com/scd