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. 2013 Feb 26;65(2):240–246. doi: 10.1080/01635581.2013.756533

FIG. 2.

FIG. 2.

Expression of lung cancer-related proto-oncogenes in the lung tissue of experimental mice. The values given in ppm on the x-axes represent the concentration of deuterium in the deuterium-depleted drinking water (DDW) (25 ppm) and control drinking water (150 ppm). DMBA: 7,12-dimethylbenz(a)anthracene. Effects of levels of deuterium in drinking water on Kras gene expression in lungs of female and male mice are graphed in panels A and D; effects on Bcl2 expression in lungs of female and male mice are shown in panels B and E, whereas Myc expression in lungs of female and male mice are seen in panels C and F, respectively. There was significant (∗p < 0.05) difference in gene expression observed in DMBA-treated female animals consuming DDW or tap water at all the examined genes. (150 ppm = normal drinking water without DMBA-treatment, 150 ppm + DMBA = normal drinking water with DMBA-treatment, 25 ppm = deuterium-depleted drinking water without DMBA-treatment, 25 ppm + DMBA = deuterium-depleted drinking water with DMBA-treatment).