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. Author manuscript; available in PMC: 2013 Apr 2.
Published in final edited form as: Cell. 2012 Jun 8;149(6):1339–1352. doi: 10.1016/j.cell.2012.04.028

Figure 2. Functional Conservation versus Functional Repurposing.

Figure 2

(A) Distribution of correlation coefficients between GI profiles, with extreme cases of pairwise correlation and anti-correlation annotated as gene a - gene b. (B) Scatter plot of correlation coefficients comparing Sc data reported by Hoppins et al versus Costanzo et al. See Table S1 for a list of highly correlated profiles and highly reproducible (green) correlation relationships. (C) Scatter plot of correlation coefficients comparing GI profiles for Sp versus Sc. Highlighted examples of pairwise relationships that are correlated in Sp but not Sc are listed below the scatter plot. Bold indicates functional relationships explored in this study. See Table S1 for additional examples of correlated pairwise relationships conserved between Sp and Sc (green), and pairwise relationships that are correlated in Sc but not Sp (cyan) or Sp but not Sc (red). (D) Amino acid sequence comparison-based statistics for Sp versus Sc orthologs highlighted in 2B,C. Horizontal bars = median values. See Table S1 for BLAST scores, E-VALUEs, percent identities and overlap. (E) Functional Repurposing: the functions of ancestral genes are unknown, but for the factors studied here the apparent gene-to-gene and gene-to-phenotype relationships in Sp are divergent from those in Sc.