FIG. 1.

Rationality and schematic representation of the study. (A) Both adult stem cells (red cells seeded on the outer layer of the hybrid scaffolds) and olfactory ensheathing cells (OECs) (green cells encapsulated on the hydrogel) secreted factors that can affect the biological behavior of each other. (B) Transwell system used to study the effects of cell secretome. (C) Hybrid scaffold developed and previously characterized [5]. (D) Schematic representation of the scaffold implantation, with the SPCL layer at the vertebra bone level and the hydrogel at the nervous tissue level. Color images available online at www.liebertpub.com/scd