. Author manuscript; available in PMC: 2013 Apr 2.

Published in final edited form as: J Clin Pharmacol. 2010 Jan 26;50(6):714–720. doi: 10.1177/0091270009353031

Table 1.

Pharmacokinetics of Bupropion, Hydroxybupropion and Enantiomers

	Bupropion	R Bupropion	S Bupropion	Hydroxybupropion	R,R Hydroxybupropion	S,S Hydroxybupropion
Cmax (ng/mL)^a,^b	213±93.7	66.2±33.9	147±59.8	388±135	356±118	31.5±17.0
Tmax (hrs)^b	4.0±1.8	4.2±2.1	4.0±1.8	16.6±4.9	16.6±4.9	8.8±5.8
T1/2 (hrs)	22.9±18.0	34.6±52.1	19.9±13.3	43.0±29.7	48.7±29.4	34.8±14.4
AUC 0–72 (µg hr/L)^a,^b	2021±592	617±169	1404±423	16400±6698	15800±5828	912±487
AUC 0–∞ (µg hr/L) ^a,^b	2329±953	872±695	1549±607	31600±14800	30300±14300	1297±719
Cl/F (L/hr)^a	73.5±27.2	113±44.6	55.8±22.6	N/A	N/A	N/A
Clr L/hr)^a, ^b	1.3±0.6	0.7±0.4	1.5±0.7	0.4±0.2	0.45±0.2	1.8±0.9
Vz/F (L)^a	2108±1039	7192±3606	2852±1421	N/A	N/A	N/A

– p<0.05 R bupropion vs S bupropion

– p<0.05 R,R bupropion vs S,S bupropion

Data presented as mean ± standard deviation.