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. Author manuscript; available in PMC: 2013 Apr 2.
Published in final edited form as: Org Biomol Chem. 2010 Jul 29;8(19):4281–4288. doi: 10.1039/c0ob00025f

Table 3.

Structures and affinities of compound 1 and analogues 41–49

graphic file with name nihms452106t10.jpg
Compound X Y Ki/µMa
1 Cl Cl 9.6 ± 0.22
41 H H 84 ± 2.2
42 H Cl 23 ± 0.7
43 CH3 CH3 23 ± 3.0
44 H CH3O 89 ± 20
45 F CF3 17 ± 2.7
46 Br NO2 26 ± 2.3
47 NO2 Cl 22 ± 6.1
48 NO2 Br 11 ± 1.2
49 CF3 Cl 7.2 ± 0.7
a

Ki values are shown as mean ± SEM based on at least three individual measurements.