Table 2. Rare Gastrointestinal Manifestations of CMV Infection.
Age, y | Sex | Recipient | Donor | Time b | Type of transplantation | Induction or antirejection medication | Signs | Diagnosis | Treatment |
37 | F a | + | + | 30 d | kidney | Anti-CD52 | Abdominal pain, bloody peritoneal fluid, leukopenia | Peritoneal fluid RT-PCR c, CMV-pp65 d | Peritoneal-catheter removal, medical therapy (34) |
41 | F | - | - | 6 mo | - | ATG a | Abdominal pain, Pancreatitis | RT-PCR | Medical therapy (36) |
46 | F | + | + | 2 mo | kidney | Basiliximab | Fever, abdominal pain, duodenal vasculitis | RT-PCR | Histology e, medical therapy (33) |
50 | M a | + | + | 8 wk | Kidney, Liver | ATG | Abdominal pain, duodenal vasculitis, obstruction | RT-PCR | Histology, surgical resection (35) |
58 | F | + | + | 6 mo | kidney | - | Fever, leukopenia, thrombocytopenia, painful hemorrhoid | CMV-PP65 Ag | Histology (32) |
44 | M | ? | - | 2 mo | Kidney | OKT3 F | Abdominal pain, diarrhea, leukopenia, large colonic veins thrombosis | Histology | Total colectomy (30) |
62 | M | + | + | 4 y | heart | - | Abdominal pain, hematochezia, colonic stenosis | Histology | Surgical resection (31) |
aAbbreviation: ATG, antithymocyte globuline; F, female; M,male
bTime at which the complication presents after transplantation.
cRT-PCR, detection of CMV-DNA in plasma or other bodily fluid by real-time polymerase chain reaction.
dCMV-pp65, detection of CMV-PP65 antigen.
eHistology, that pathologic changes including CMV inclusion bodies have been found in involved tissues.
FOKT3 is an anti Tcell murine monoclonal anibody.