Table 3.
Adjusted Relative Risks and 95% Confidence Intervals for any colorectal adenoma according to DM status (n = 2,663)
| Outcome | DM+ (%) |
DM− (%) |
Unadjusted RR (95% CI) |
Age-adjusted RR (95% CI) |
Multivariate-adjusted (95% CI) |
|---|---|---|---|---|---|
| Total adenoma | 81 (43.8) | 953 (38.5) | 1.25 (0.92–1.68) | 1.17 (0.86–1.58) | 1.16 (0.83–1.63) |
| P=0.15 | P=0.32 | P=0.39 | |||
| Left adenoma | 46 (24.9) | 534 (21.6) | 1.20 (0.85–1.70) | 1.13 (0.80–1.60) | 1.18 (0.80–1.74) |
| P=0.29 | P=0.50 | P=0.39 | |||
| Right adenoma | 56 (30.3) | 594 (24.0) | 1.38 (0.99–1.91) | 1.31 (0.94–1.81) | 1.22 (0.85–1.76) |
| P=.055 | P=0.11 | P=0.29 | |||
| Number of left adenomasb | |||||
| 0 | |||||
| 1 | 139 (75.1) | 1,944 (78.5) | 1.21 (0.85–1.70) | 1.13 (0.80–1.59) | 1.17 (0.80–1.72) |
| ≥2 | 32 (17.3) | 377 (15.2) | P=0.29 | P=0.50 | P=0.41 |
| 15 (7.6) | 157 (6.3) | ||||
| Number of right adenomasb | |||||
| 0 | 129 (69.7) | 1,884 (76.0) | 1.42 (1.03–1.96) | 1.33 (0.96–1.84) | 1.22 (0.85–1.75) |
| 1 | 31 (16.8) | 384 (15.5) | P=0.03 | P=0.09 | P=0.28 |
| ≥2 | 25 (13.5) | 210 (8.5) | |||
| Advanced adenoma | 19 (10.3) | 231 (9.3) | 1.11 (0.68–1.82) | 1.03 (0.62–1.68) | 0.82 (0.45–1.49) |
| P=0.67 | P=0.92 | P=0.51 |
a
Adjusted for age, sex, educational level, BMI, smoking status, alcohol consumption, family history of CRC, total fat consumption, dietary fiber consumption, red meat consumption, study number and trial treatment assignment.
b
Number of adenomas was analyzed by ordinal logistic regression analysis assuming the proportional odds assumption (i.e., same regression coefficients for all outcome categories). The odds ratio can be interpreted as constant across all possible outcome categories.