Table 2.
A | Irisin | Age | BMI | Biceps circum. |
Fat-free mass |
Fat mass |
WHR | Insulin | HOMA -IR |
LnAdiponectin | Leptin | Cortisol | Estradiol | Testosterone | Ghrelin | IGF-1 | IGFBP- 3 |
IGF-1/ IGFBP-3 |
Glucose | Total Cholesterol |
LDL | H HDL |
TG | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Irisin (ng/ml) |
r | 1.00 | ||||||||||||||||||||||
p | ․ | |||||||||||||||||||||||
Age (years) |
r | −0.28 | 1.00 | |||||||||||||||||||||
p | <0.01 | ․ | ||||||||||||||||||||||
BMI (kg/m2) | r | 0.16 | −0.19 | 1.00 | ||||||||||||||||||||
p | 0.09 | 0.04 | ․ | |||||||||||||||||||||
Biceps Circumference (RU) |
r | 0.27 | −0.07 | 0.45 | 1.00 | |||||||||||||||||||
p | 0.02 | 0.51 | <0.01 | ․ | ||||||||||||||||||||
Fat-free mass (kg) | r | 0.21 | −0.39 | 0.74 | 0.35 | 1.00 | ||||||||||||||||||
p | 0.02 | 0.01 | <0.01 | <0.01 | ․ | |||||||||||||||||||
Fat mass (kg) | r | 0.18 | −0.26 | 0.96 | 0.49 | 0.88 | 1.00 | |||||||||||||||||
p | 0.06 | <0.01 | <0.01 | <0.01 | <0.01 | ․ | ||||||||||||||||||
Waist-to-hip ratio (WHR) |
r | 0.16 | −0.09 | 0.39 | 0.27 | 0.31 | 0.41 | 1.00 | ||||||||||||||||
p | 0.08 | 0.33 | <0.01 | 0.01 | 0.01 | <0.01 | ․ | |||||||||||||||||
Insulin (µIU/ml) |
r | −0.17 | 0.08 | −0.47 | −0.36 | −0.34 | −0.46 | −0.43 | 1.00 | |||||||||||||||
p | 0.09 | 0.45 | <0.01 | <0.01 | <0.01 | <0.01 | 0.01 | ․ | ||||||||||||||||
HOMA-IR | r | −0.15 | 0.01 | −0.34 | −0.23 | −0.23 | −0.33 | −0.38 | 0.84 | 1.00 | ||||||||||||||
p | 0.14 | 0.96 | <0.01 | 0.05 | 0.03 | 0.01 | 0.01 | <0.01 | ․ | |||||||||||||||
LnAdiponectin (µg/ml) |
r | −0.27 | 0.24 | −0.23 | −0.05 | −0.24 | −0.23 | −0.37 | 0.32 | 0.25 | 1.00 | |||||||||||||
p | <0.01 | 0.01 | 0.02 | 0.66 | 0.01 | 0.02 | <0.01 | 0.01 | 0.02 | ․ | ||||||||||||||
Leptin (ng/ml) | r | 0.09 | −0.18 | 0.69 | 0.48 | 0.62 | 0.72 | 0.26 | −0.53 | −0.42 | −0.04 | 1.00 | ||||||||||||
p | 0.39 | 0.07 | <0.01 | <0.01 | 0.01 | 0.01 | 0.01 | <0.01 | <0.01 | 0.66 | ․ | |||||||||||||
Cortisol (µg/dl) | r | −0.12 | −0.09 | 0.11 | −0.09 | 0.09 | 0.12 | 0.10 | −0.09 | −0.16 | −0.01 | 0.18 | 1.00 | |||||||||||
p | 0.22 | 0.32 | 0.24 | 0.45 | 0.33 | 0.20 | 0.29 | 0.38 | 0.13 | 0.88 | 0.08 | ․ | ||||||||||||
Estradiol (pg/ml) |
r | 0.24 | −0.35 | 0.33 | 0.11 | 0.26 | 0.29 | 0.12 | −0.19 | −0.15 | −0.29 | 0.25 | 0.03 | 1.00 | ||||||||||
p | 0.01 | <0.01 | <0.01 | 0.33 | 0.01 | 0.01 | 0.20 | 0.06 | 0.15 | <0.01 | 0.01 | 0.79 | ․ | |||||||||||
Free Testosterone (pg/ml) |
r | −0.09 | −0.06 | −0.03 | −0.16 | −0.01 | −0.02 | −0.15 | <0.01 | −0.01 | 0.02 | −0.08 | −0.05 | 0.04 | 1.00 | |||||||||
p | 0.35 | 0.53 | 0.79 | 0.16 | 0.91 | 0.85 | 0.11 | 0.98 | 0.95 | 0.84 | 0.44 | 0.60 | 0.67 | ․ | ||||||||||
Ghrelin (pg/ml) | r | 0.25 | −0.14 | 0.01 | −0.09 | −0.08 | −0.01 | 0.12 | 0.12 | 0.07 | 0.02 | −0.08 | 0.02 | 0.16 | −0.10 | 1.00 | ||||||||
p | 0.02 | 0.18 | 0.92 | 0.41 | 0.42 | 0.90 | 0.28 | 0.27 | 0.56 | 0.88 | 0.49 | 0.86 | 0.13 | 0.34 | ․ | |||||||||
IGF-1 (ng/ml) |
r | 0.32 | −0.27 | −0.09 | 0.03 | −0.01 | −0.07 | 0.10 | −0.20 | −0.10 | −0.12 | −0.04 | 0.01 | 0.12 | −0.11 | −0.02 | 1.00 | |||||||
p | 0.01 | 0.01 | 0.36 | 0.82 | 0.90 | 0.51 | 0.34 | 0.06 | 0.32 | 0.26 | 0.71 | 0.94 | 0.26 | 0.29 | 0.83 | ․ | ||||||||
IGFBP-3 (µg/ml) | r | 0.01 | 0.02 | 0.07 | 0.07 | 0.03 | 0.09 | 0.09 | −0.03 | 0.01 | <0.01 | 0.05 | −0.10 | −0.04 | −0.02 | −0.06 | 0.20 | 1.00 | ||||||
p | 0.95 | 0.81 | 0.47 | 0.57 | 0.74 | 0.40 | 0.36 | 0.75 | 0.90 | 0.97 | 0.63 | 0.33 | 0.70 | 0.86 | 0.60 | 0.04 | ․ | |||||||
IGF-1/IGFBP-3 Ratio | r | 0.21 | −0.25 | −0.06 | 0.06 | 0.09 | −0.01 | 0.05 | −0.16 | −0.13 | −0.16 | 0.00 | 0.05 | 0.05 | −0.06 | 0.02 | 0.47 | −0.55 | 1.00 | |||||
p | 0.04 | 0.01 | 0.54 | 0.61 | 0.36 | 0.93 | 0.60 | 0.13 | 0.22 | 0.14 | 0.97 | 0.64 | 0.65 | 0.60 | 0.85 | <0.01 | <0.01 | ․ | ||||||
Glucose (mg/dl) | r | 0.25 | −0.13 | 0.48 | 0.23 | 0.46 | 0.51 | 0.31 | −0.34 | −0.08 | −0.23 | 0.44 | −0.06 | 0.22 | −0.07 | 0.11 | 0.13 | 0.07 | 0.13 | 1.00 | ||||
p | 0.01 | 0.17 | <0.01 | 0.05 | <0.01 | <0.01 | <0.01 | <0.01 | 0.46 | 0.02 | <0.01 | 0.54 | 0.02 | 0.49 | 0.32 | 0.20 | 0.51 | 0.22 | ․ | |||||
Total Cholesterol (mg/dl) |
r | −0.24 | 0.36 | 0.01 | −0.06 | −0.12 | −0.04 | 0.05 | −0.10 | −0.10 | 0.16 | 0.01 | 0.15 | −0.01 | 0.11 | −0.02 | −0.17 | 0.03 | −0.05 | −0.05 | 1.00 | |||
p | 0.01 | <0.01 | 0.94 | 0.63 | 0.20 | 0.69 | 0.59 | 0.36 | 0.32 | 0.10 | 0.91 | 0.12 | 0.89 | 0.27 | 0.85 | 0.11 | 0.78 | 0.62 | 0.61 | ․ | ||||
LDL Cholesterol (mg/ dl) |
r | −0.17 | 0.34 | 0.05 | −0.05 | −0.09 | <0.01 | 0.08 | −0.11 | −0.10 | 0.08 | 0.02 | 0.09 | 0.03 | 0.10 | <0.01 | −0.14 | 0.03 | −0.02 | 0.01 | 0.95 | 1.00 | ||
p | 0.08 | <0.01 | 0.63 | 0.67 | 0.33 | 1.00 | 0.39 | 0.31 | 0.36 | 0.45 | 0.85 | 0.38 | 0.73 | 0.33 | 0.97 | 0.19 | 0.77 | 0.85 | 0.96 | <0.01 | ․ | |||
HDL Cholesterol (mg/dl) |
r | −0.28 | 0.13 | −0.35 | −0.16 | −0.29 | −0.34 | −0.29 | 0.35 | 0.25 | 0.42 | −0.22 | 0.13 | −0.19 | 0.01 | −0.03 | −0.10 | 0.02 | −0.12 | −0.36 | 0.16 | −0.08 | 1.00 | |
p | 0.01 | 0.18 | <0.01 | 0.18 | 0.01 | 0.01 | <0.01 | <0.01 | 0.02 | <0.01 | 0.03 | 0.17 | 0.04 | 0.93 | 0.76 | 0.32 | 0.88 | 0.26 | <0.01 | 0.09 | 0.40 | ․ | ||
Triglycerides (mg/dl) | r | −0.07 | 0.04 | 0.24 | 0.10 | 0.14 | 0.21 | 0.27 | −0.38 | −0.35 | −0.18 | 0.20 | 0.19 | 0.23 | 0.12 | −0.10 | −0.13 | −0.20 | 0.14 | 0.19 | 0.54 | 0.51 | −0.29 | 1.00 |
p | 0.48 | 0.65 | 0.01 | 0.42 | 0.13 | 0.03 | <0.01 | <0.01 | <0.01 | 0.07 | 0.05 | 0.05 | 0.02 | 0.24 | 0.37 | 0.20 | 0.06 | 0.19 | 0.05 | <0.01 | <0.01 | <0.01 | ․ |
B | Irisin | Age | BMI | Fat-free mass | Insulin | Adiponectin | Leptin | Cortisol | |
---|---|---|---|---|---|---|---|---|---|
Irisin (ng/ml) |
r | 1.00 | |||||||
p | ․ | ||||||||
Age (years) |
r | −0.53 | 1.00 | ||||||
p | 0.05 | ․ | |||||||
BMI (kg/m2) |
r | −0.02 | −0.17 | 1.00 | |||||
p | 0.96 | 0.55 | ․ | ||||||
Fat-free mass (kg) |
r | −0.06 | 0.02 | 0.64 | 1.00 | ||||
p | 0.84 | 0.94 | 0.02 | ․ | |||||
Insulin (µIU/ml) |
r | 0.54 | −0.43 | −0.04 | −0.17 | 1.00 | |||
p | 0.04 | 0.12 | 0.89 | 0.58 | ․ | ||||
Adiponectin (µg/ml) |
r | −0.32 | 0.38 | −0.09 | −0.37 | −0.52 | 1.00 | ||
p | 0.26 | 0.18 | 0.77 | 0.22 | 0.06 | ․ | |||
Leptin (ng/ml) |
r | 0.19 | −0.20 | −0.16 | −0.39 | −0.41 | 0.42 | 1.00 | |
p | 0.52 | 0.50 | 0.57 | 0.19 | 0.14 | 0.13 | ․ | ||
Cortisol (µg/dl) |
r | −0.25 | 0.47 | 0.15 | −0.05 | 0.12 | −0.15 | −0.45 | 1.00 |
p | 0.47 | 0.14 | 0.67 | 0.88 | 0.73 | 0.67 | 0.16 | ․ |
r and p values are shown with significant correlations in bold. (A) Pearson’s correlation coefficients of study variables of the cross-sectional study on healthy subjects. (B) Spearman’s bivariate correlation coefficients of study variables of the study on obese subjects undergoing bariatric surgery (assessed preoperatively), RU: relative unit.