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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Metabolism. 2012 Sep 25;61(12):1725–1738. doi: 10.1016/j.metabol.2012.09.002

Table 3.

Multivariate regression analysis of anthropometric, hormonal, and metabolic factors in relation to circulating irisin levels in the cross-sectional study on healthy subjects.

β1 β2 β3 β4 β5 β6 β7
Anthropometric characteristics
  Age (yr) −0.28**   -   -   -   -   -   -
  BMI(kg/m2)   0.16   0.11   0.12   0.12   0.03 −0.03 −0.07
  Biceps circumference(RU)   0.27 *   0.27*   0.29**   0.31**   0.28*   0.25*   -
  Fat free mass(kg)   0.21 *   0.12   0.12   0.13   0.09   -   0.03
  Body fat(kg)   0.18   0.11   0.12   0.13   0.05 −0.03 −0.02
  Waist-to-hip ratio   0.16   0.14   0.15   0.15   0.13   0.11 −0.04
Hormonal parameters
  Leptin a(ng/ml)   0.16   0.11   0.10   0.11   0.07   0.04   0.08
  Adiponectin a(µg/ml) −0.27 ** −0.20* −0.20* −0.20* −0.18 − 0.18 −0.10
  Insulin (µIU/ml) −0.17 −0.15 −0.15 −0.14 −0.10 −0.06   0.05
  HOMA-IR −0.15 −0.16 −0.16 −0.15 −0.12 −0.09 −0.04
  Cortisol (µg/dl) −0.12 −0.14 −0.14 −0.14 −0.15 −0.16 −0.15
  Estradiol a(pg/ml)   0.35**   0.29**   0.29**   0.29**   -   -   -
  Free testosterone(pg/ml) −0.09 −0.11 −0.11 −0.11 −0.14 −0.14 −0.11
  Ghrelin(pg/ml)   0.25*   0.22**   0.21*   0.21*   0.19   0.22   0.16
  IGF-1 (ng/ml)   0.32**   0.28**   0.27**   0.27**   0.26**   0.30**   0.29*
  IGFBP-3 (µg/ml)   0.01   0.13   0.02   0.00   0.01   0.00 −0.07
  IGF-1/IGFBP-3   0.21 *   0.16   0.16   0.17   0.20   0.22   0.28
Metabolic parameters
  Glucose a(µg/ml)   0.25**   0.24*   0.24*   0.25**   0.19   0.15   0.08
  Total cholesterol (µg/ml) −0.24** −0.16 −0.16 −0.16 −0.18 −0.18 −0.25
  LDL cholesterol (µg/ml) −0.17 −0.08 −0.08 −0.07 −0.10 −0.10 −0.17
  HDL cholesterol (µg/ml) −0.28** −0.25** −0.26** −0.27** −0.25** −0.23* −0.21
  Triglycerides(µg/ml) −0.07 −0.06 −0.06 −0.05 −0.13 −0.14 −0.19

β1: unadjusted bivariate linear regression coefficient.

β2: multivariate linear regression coefficient adjusted for age.

β3:multivariate linear regression coefficient adjusted for age, menopausal status.

β4: multivariate linear regression coefficient adjusted for age, menopausal status, and smoking status.

β5: multivariate linear regression coefficient adjusted for age, menopausal status, smoking status, and estradiol levels (logarithmically transformed).

β6: multivariate linear regression coefficient adjusted for age, menopausal status, smoking status, estradiol levels (logarithmically transformed), and fat-free mass.

β7: multivariate linear regression coefficient adjusted for age, menopausal status, smoking status, estradiol levels (logarithmically transformed), and biceps circumference.

RU: relative unit, smoking and menopausal status were assessed as described in Table 1A.

a

Values were logarithmically transformed.

*

Significant correlation (p <0.05).

**

Significant correlation (p <0.01).