Table 2.
entry | yielda (%) |
eeb (%) |
entry | yielda (%) |
eeb (%) |
||
---|---|---|---|---|---|---|---|
1 | 90 | 91 | 11d | 86 | 90 | ||
2 | 91 | 91 | 12 | 72 | 90 | ||
3c | 83 | 88 | 13 | 87 | 94 | ||
4c | 82 | 92 | 14 | 89 | 93 | ||
5c | 78 | 88 | 15 | 82 | 92 | ||
6 | 87 | 93 | 15d | 76 | 92 | ||
7 | 91 | 95 | 17c | 84 | 93 | ||
8 | 89 | 92 | 18 | 90 | 90 | ||
9 | 70 | 96 | |||||
10 | 80 | 96 | 19 | 33 | 44 |
Isolated yield.
Determined by SFC using chiral stationary phase.
6 mol % each AgOAc and (S)-16 were employed.
6 mol % each AgOAc and (S)-16 were employed at 0.1 M reaction concentration.