Figure 3.

Pathological lesions in the brain (A, B) & spinal cord (C, D). The most severe white matter lesions were observed in the cerebellum (A: asterisk) and cervical spinal cord (C: framed area). Macroscopic examination revealed bilateral, symmetrical lesions in the lateral funiculi of the cervical cord segments only. In transverse sections, these lesions appeared as well-demarcated, whitish, opaque discoloured areas (C: framed area). The cerebellar lesions spared the fibres adjacent to the roof nuclei (A: arrow). Nuclear degeneration was most severe in the raphe nuclei (B) and medial vestibular nuclei (not shown). Note the extensive juxtaneuronal vacuolisation (B: asterisk). The affected spinal cord segments show demyelination, astrogliosis and astrocytosis (D: white arrowhead) with gemistocytes (D: black arrowheads). Within the grey matter, hypoplasia of the dorsal and ventral horn (C: black arrow) is evident. Scale bars: A: 1.5 cm; B: 100 μm; C: 2 mm; D: 35 μm.