Table 2.
Urine GAG* excretion
| Comparator 0.5 mg/kg/week (N = 11 ) | Idursulfase beta 0.5 mg/kg/week (N = 10) | Idursulfase beta 1.0 mg/kg/week (N = 10 ) | |
|---|---|---|---|
|
Baseline |
129.1(±59.9) |
164(±53.1) |
124.7(±36.1) |
|
4 weeks |
105.6(±56) |
112.3(±56.7) |
73.5(±35.7) |
|
8 weeks |
109.8(±67.8) |
103.4(±56.4) |
67.1(±21.7) |
|
12 weeks |
102.5(±55) |
110.9(±44.1) |
71.9(±24.4) |
|
16 weeks |
111.1(±69.7) |
107(±46.2) |
63(±24.6) |
|
20 weeks |
104.6(±62.6) |
111.6(±46.5) |
70.7(±24.5) |
| 24 weeks | 105.3(±59.6) | 114.4(±45) | 74.5(±27.3) |
All values are menas ± SD.
*reference range: < 175 CPC unit/g Cr for ≤ 9 years, < 85 CPC unit/g Cr for > 9 years.