Table 9.
TRIAL II: Description of histopatological picture of internal organs in male and female rats after oral administration of 0.75 g and 7.5 g Maca-GO per kg body weight during 90 day period
| Group/Sex/Organ | Description of histopatological picture 0.75 g/kg | Description of histopatological picture 7.5 g/kg |
|---|---|---|
| Control Group | ||
| Male | ||
| Liver | single inflammations with lymphocytes present but cells appearance normal | single concentrated intracell inflammations within normal cell structure |
| pancreas | Normal – No changes detecteda | Normal – No changes detected |
| spleen | Normal –single hemosyderyne deposits | Normal –single hemosyderyne deposits |
| kidneys | Sporadic cysts and inflammations of cells in cortical layer of cells | Sporadic cysts and inflammations of cells in cortical layer of cells |
| testes | Normal – No changes detected | Normal – No changes detected |
| Female | ||
| Liver | Single concentrated cell inflammations but liver cells normal | Single concentrated cell inflammations within normal cell structure |
| pancreas | Normal – No changes detected | Normal – No changes detected |
| spleen | Cells inflamed with hemosyderine deposits | Cells inflamed with hemosyderine deposits |
| uterus | abscesses embedded in the epithelial layer | single abscesses in the epithelium |
| Maca-GO Group | ||
| Male | ||
| Liver | separate concentrations of lymphocytes | Normal – No changes detected |
| pancreas | Normal – No changes detected | Normal – No changes detected |
| spleen | Normal – traces of fresh vasculature | N/D |
| kidneys | local cysts in nephrite layer with a homogenous eozynophyllic contents | N/D |
| testes | Normal – No changes detected | Normal – No changes detected |
| Female | ||
| Liver | Normal – No changes detected | separate concentrations of lymphocytes within normal cell structure |
| pancreas | Normal – No changes detected | N/D |
| uterus | distorted cell structure of the wall | N/D |
| kidneys | single concentrations of lymphocytes in cortical layer and enlarged lumen of nephrites filled with homogenous eosynophyllic substance | single concentrations of lymphocytes in cortical layer and enlarged lumen of nephrites filled with homogenous eosynophyllic substance |
a
Normal – No changes detected, No histopathological changes detected in microscopic examination–picture of individual slides considered as “normal”; N/D, Not determined.