Table 7.
Application of the proposed methods for the determination of the studied drugs in pharmaceutical preparations
| Pharmaceutical preparations | Proposed methods |
Reference methods |
|||
|---|---|---|---|---|---|
| Amount taken (μg/ml) | Amount found (μg/ml) | Recovery (%) | Taken (μg/ml) | Recovery (%) | |
| At 610 nm | |||||
| Glucobay 50 tabletsa | 5.0 | 5.008 | 100.16 | ||
| (Acarbose, 50 mg/tablet) | 10.0 | 10.091 | 100.91 | ||
| 15.0 | 15.218 | 101.45 | |||
| x ± S.D. | 100.84 ± 0.648 | 100.400 ± 0.400 | |||
| t | 1.002 | (2.776)c | |||
| F | 2.62 | (19.00) | |||
| Glyset 50 mg tabletsb | 2.0 | 1.978 | 98.90 | 60.0 | 97.26 |
| (Miglitol, 50 mg/tablet) | 4.0 | 4.025 | 100.63 | 80.0 | 98.71 |
| 8.0 | 8.099 | 101.24 | 100.0 | 99.66 | |
| x ± S.D. | 100.26 ± 1.214 | 98.54 ± 1.208 | |||
| t | 1.740 | (2.776)c | |||
| F | 1.01 | (19.00) | |||
| At 525 nm | |||||
| Glucobay 50 tablets | 4.0 | 4.044 | 101.10 | ||
| (Acarbose, 50 mg/tablet) | 10.0 | 10.062 | 100.62 | ||
| 20.0 | 20.220 | 101.10 | |||
| x ± S.D. | 100.94 ± 0.277 | 100.400 ± 0.400 | |||
| t | 1.923 | (2.776)c | |||
| F | 2.086 | (19.00) | |||
| Glyset 50 mg tablets | 2.0 | 1.987 | 99.35 | 60.0 | 97.26 |
| (Miglitol, 50 mg/tablet) | 4.0 | 4.070 | 101.75 | 80.0 | 98.71 |
| 8.0 | 8.036 | 100.45 | 100.0 | 99.66 | |
| x ± S.D. | 100.52 ± 1.201 | 98.54 ± 1.208 | |||
| t | 2.014 | (2.776)c | |||
| F | 1.01 | (19.00) | |||
Each result is the average of three separate determinations.
Product of Alkan Pharma S.A.E., Egypt under licence of Bayer-Leverkusen, Germany, Egypt;
Product of Sigma Pharma-ceutical industries, Egypt;
Figures in parentheses are the tabulated t and F values, respectively at p=0.05 (32).