Table 7.

Monthly changes in values of individual symptoms determined according to Kupperman’s Menopausal Index (KMI) recorded for APPMM treatment sequence (n=11) between Admission (A), and four sampling points at monthly intervals (Month Model)^a with two months Placebo (P) followed by two months Maca-GO (M)

Symptom as per KMI	Admission A	After 1m P	After 2m P	After 1m M	After 2m M	SED (±)b	Pc	Placebo	Maca	SEDb	Pc
Hot flushes	2.20	1.70	2.60	1.00	0.83	0.251	<0.001	2.15	0.92	0.17	<0.001
Excessive sweating	2.10	0.70	2.20	1.10	0.71	0.396	<0.001	1.45	0.91	0.29	0.066
Interrupted sleep	2.30	1.20	1.80	0.60	0.57	0.399	<0.001	1.50	0.59	0.29	0.004
Nervousness	2.50	1.00	1.90	0.30	0.14	0.262	<0.001	1.45	0.22	0.18	<0.001
Depression	1.30	0.40	0.20	0.50	0.43	0.354	0.034	0.30	0.46	0.20	0.407
Balance	0.90	0.10	0.10	0.20	0.00	0.199	<0.001	0.10	0.10	0.10	1.000
General weakness	1.90	1.10	0.60	1.00	0.14	0.397	0.001	0.85	0.57	0.28	0.318
Joint pain	1.20	0.40	0.40	0.60	0.25	0.375	0.115	0.40	0.43	0.23	0.912
Headaches	1.00	0.40	0.10	0.20	0.14	0.237	0.002	0.25	0.17	0.13	0.563
Heart palpitations	1.10	0.20	0.20	0.20	0.14	0.263	0.003	0.20	0.17	0.13	0.832
Numbness hands & legs	0.40	0.00	0.20	0.10	0.14	0.166	0.189	0.10	0.12	0.10	0.836
Total value for KMI symptoms	16.9	7.20	10.30	5.80	3.51	0.185	<0.001	19.60	9.40	1.31	<0.001

^aFor explanation see Table 1;

^bSED, Standard error of differences;

^cP, Probabilities of significance. ns, not significant at P>0.05; <0.05, significance at 5% probability level; <0.01, significance at 1% probability level; <0.001, significance at 0.1% probability level. Scoring index: 0, symptom not experienced; 1, occasionally; 2, often; 3, very often; Kupperman’s Indexing Factors: for K-1, ×4; K-2 to K-5, ×2; the remaining, ×1).