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. 2008 Sep;4(3):204–211.

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© Sébastien Amoureux et al. Licensee Master Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Oxidative profile evolution of patients undergoing cardiac surgery under Cardiopulmonary Bypass (CPB). A, represents the CP^• (CPH (1-hydroxy-3-carboxy-pyrrolidine) oxidation product) characteristic ESR triplet signal recorded at room temperature on an ESP 300 EX-band spectrometer; B, represents this signal evolution in plasma of the patients. Patients presented an increase in plasma capacities to produce superoxide that oxidize CPH during CPB that continued after Aortic Cross Unclamping (ACU) (*p<0.05; Comparison: per-CPB vs. pre-CPB and post-ACU vs. pre-CPB). Results are expressed as a percentage of pre-CPB ESR signal measured in plasma after 1h incubation with CP-H (1 mM); C, shows the increase in Endogenous Peroxidase Activity (EPA; expressed in mIU/mL) during CPB (**p<0.01; Comparison: per-CPB vs. pre-CPB and post-ACU vs. pre-CPB).