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Time course of changes in pain threshold after topical application of 1% diclofenac patch or other NSAID patch on the pain threshold induced by 10% brewer’s yeast suspension injection in rat hind footpad paw. Data are expressed as the mean ± S.D. of animals. **p<0.01, ***p<0.001: Significantly different from the analgesia control group; #p<0.05: Significantly different from the indomethacin patch group. (Dunnett’s test).
