Table 5.
Association analysis among PLD1 SNPs, smoking status, age and gender in non-small cell lune cancer patients
| SNP | Geno-type | Gender (%) |
Survival (%) |
Smoking (%) |
Age-years (%) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | P | Death | N/Da | P | Never | Ever | P | Age ≥60 | Age <60 | P | ||
| G2660T | GG | 125 (89.9) | 67 (93.0) | 0.578 | 88 (82.3) | 104 (91.2) | 0.967 | 94 (92.2) | 98 (89.9) | 0.648 | 106 (91.4) | 86 (90.5) | 0.642 |
| GT+TT | 14 (10.1) | 5 (7.0) | 9 (17.7) | 10 (8.8) | 8 (7.8) | 11 (10.1) | 10 (8.6) | 9 (9.5) | |||||
| A2690T | AA | 123 (88.5) | 67 (93.0) | 0.150 | 88 (82.3) | 102 (89.5) | 0.991 | 92 (90.2) | 98 (89.9) | 0.932 | 107 (92.2) | 83 (76.3) | 0.131 |
| AT+TT | 16 (11.5) | 5 (7.0) | 9 (17.7) | 12 (10.5) | 10 (9.8) | 11 (10.1) | 9 (7.8) | 12 (23.7) | |||||
| A2698C | AA | 34 (24.4) | 16 (22.2) | 0.536 | 14 (14.4) | 36 (31.6) | 0.012 | 21 (20.6) | 29 (26.6) | 0.481 | 29 (25.0) | 21 (22.1) | 0.369 |
| AC+CC | 105 (75.6) | 56 (77.8) | 83 (85.6) | 78 (68.4) | 81 (79.4) | 80 (73.4) | 87 (75.0) | 74 (77.9) | |||||
| A2708C | AA | 127 (91.4) | 63 (87.5) | 0.369 | 88 (90.7) | 102 (89.5) | 0.626 | 100 (91.7) | 90 (88.2) | 0.372 | 103 (88.8) | 87 (91.6) | 0.331 |
| AC+CC | 12 (8.6) | 9 (12.5) | 9 (9.3) | 12 (10.5) | 9 (8.3) | 12 (11.8) | 13 (11.2) | 8 (8.4) | |||||
| A2744C | AA | 117 (84.2) | 67 (93.0) | 0.071 | 83 (73.2) | 101 (88.6) | 0.661 | 94 (86.2) | 90 (88.2) | 0.662 | 105 (90.5) | 79 (83.2) | 0.236 |
| AC+CC | 22 (15.8) | 5 (7.0) | 14 (26.8) | 13 (11.4) | 15 (13.8) | 12 (11.8) | 11 (9.5) | 16 (16.8) | |||||
| A2756C | AA | 117 (84.2) | 67 (93.0) | 0.071 | 84 (86.6) | 100 (87.7) | 0.651 | 96 (88.1) | 88 (86.3) | 0.628 | 99 (85.3) | 85 (89.5) | 0.528 |
| AC+CC | 22 (15.8) | 5 (7.0) | 13 (13.4) | 14 (12.3) | 13 (11.9) | 14 (13.7) | 17 (14.7) | 10 (11.5) | |||||
p-values for gender, survival, smoking and age were obtained from logistic regression analysis.
a
Non Death.