Table 1.
Effects of RA on the viability and LDH leakage in SH-SY5Y cells exposed to oxygen-glucose deprivation
| Groups | OGD | Content (μM) | Cell viability (%) | LDH leakage (%) |
|---|---|---|---|---|
| Normal |
_ |
— |
100.0 ± 4.7 |
4.1 ± 1.2 |
| Control |
+ |
— |
52.0 ± 6.8# |
24.7 ± 4.2# |
| RA | + |
1 |
59.2 ± 7.3 |
21.9 ± 2.8 |
| + |
3 |
64.2 ± 5.8* |
19.6 ± 3.5* |
|
| + |
9 |
69.0 ± 9.1** |
16.5 ± 2.1** |
|
| + |
27 |
72.8 ± 7.4** |
14.0 ± 3.1** |
|
| + | 81 | 73.5 ± 8.3** | 13.3 ± 1.7** |
After 3 h oxygen-glucose deprivation (OGD) followed by 12 h incubation with RA, cell viability and LDH leakage were assessed. RA indicated Rosmarinic acid. OGD, oxygen-glucose deprivation. Values are mean ± S.D. (n = 6). Significance was determined by one-way ANOVA followed by Dunnett's test. #P <0.01 versus normal group; *P <0.05, **P <0.01 versus Control group.