Table 3.
Effects of RA on survival, neurological scores, infarct volume and brain water content in ischemia-reperfused diabetic rats: a therapeutic time-window study
| Group | Survival (# rats) | Neurological scores (median/range) | Infarct volume (%) | Brain water content (%) | |
|---|---|---|---|---|---|
|
Diabetic |
|
10/10 |
— |
— |
77.0 ± 0.5 |
|
Vehicle-treated |
|
8/10 |
4/2 |
27.7 ± 4.7 |
79.6 ± 0.4# |
| |
1 h |
10/10 |
2/3** |
19.0 ± 4.4** |
78.8 ± 0.4** |
| RA | 3 h |
10/10 |
2/3* |
21.5 ± 4.5** |
79.0 ± 0.4* |
| 5 h |
9/10 |
3/4* |
22.8 ± 2.8* |
79.1 ± 0.4* |
|
| 7 h | 9/10 | 3/4 | 24.1 ± 4.0 | 79.3 ± 0.4 | |
Data are means ± SD, with n = 10 for each group. RA was administered at a dose of 50 mg/kg at 1 h, 3 h, 5 h and 7 h after cerebral I/R. RA indicates rosmarinic acid. Data are means ± SD. #P <0.01 vs. diabetic animals; *P <0.05, **P <0.01 vs vehicle-treated group. Cerebral infarct volumes of different groups were compared using one-way ANOVA followed by Dunnett's test. Neurological deficit scores between groups were compared using a nonparametric test.