Table 4.
Effects of RA on survival, neurological scores, blood glucose and infarct volume in ischemia-reperfused rats: a long-term study
| Group | Time (days) | Survival (# rats) | Neurological scores (median/range) | Blood glucose (mM) | Infarct volume (%) |
|---|---|---|---|---|---|
|
Vehicle |
3 |
12/15 |
4/3 |
20.3 ± 3.1 |
30.3 ± 5.1 |
| 7 |
12/15 |
3/4 |
20.5 ± 3.2 |
||
| 14 |
12/15 |
3/4 |
20.7 ± 3.4 |
||
| RA50 | 3 |
14/15 |
2/4** |
20.5 ± 2.9 |
|
| 7 |
14/15 |
2/4* |
20.4 ± 3.1 |
|
|
| 14 | 14/15 | 2/4* | 20.7 ± 3.2 | 13.9 ± 4.7** |
RA was administered at a dose of 50 mg/kg as a single intravenous bolus injection 30 minutes after cerebral I/R. RA indicates rosmarinic acid. Data are means ± SD, each group contains 15 rats. *P <0.05, **P <0.01 vs vehicle-treated group. Cerebral infarct volumes of different groups were compared using one-way ANOVA followed by Dunnett's test. Neurological deficit scores between groups were compared using a nonparametric test.